Is breast conservation therapy appropriate for mutation carriers?  

While most breast cancer patients who are mutation carriers elect mastectomy, breast conservation is an appropriate treatment option. Patients should be counseled that although their overall survival is comparable whether they are treated with BCT or mastectomy, their risk of local failure is higher...

It is important to note that in an era with increasing use of panel testing more and more functional mutations in other breast cancer susceptibility genes besides BRCA1/2 are being identified. While breast conserving therapy is not an absolute contraindication in patients with BRCA1/2...