Is carboplatin/pemetrexed as effective as cisplatin/pem in treatment of unresectable malignant pleural mesothelioma in a patient with contraindication to cisplatin?  

The combination of carboplatin/pemetrexed instead of cisplatin/pemetrexed is definitely reasonable in older mesothelioma patients and/or patients with comorbidities or concerns about poor tolerability to cisplatin. At least three phase 2 non-randomized studies evaluated the combination of carboplati...