Please select the option that best describes you:
Is history of radiation an absolute contraindication to using parathyroid hormone (PTH) analogues?
Does it depend on location of radiation, length of radiation, and time since radiation?
Answer from: at Community Practice
Hx of prior radiation was never a contraindication, it was a warning due to the known increase in osteosarcoma in patients who had prior radiation. A contraindication requires proof of harm. There was no data that radiation plus a PTH anabolic increased the risk of osteosarcoma. With the review of 1...
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Answer from: at Community Practice
Yes.
Answer from: at Community Practice
I believe past history of radiation is indeed one of the contraindications listed. Though this is largely based on theoretical concerns of increased risk of bony cancer in animal studies. I am not aware of any large set of human data that actually addresses this issue.