Is it appropriate to use a hypofractionated regimen to treat the pelvic nodes in prostate cancer?

Much of the world uses 60 Gy in 20 fractions as their new standard of care, which is endorsed by nearly all guidelines. When treating nodes people simply use 2.1 or 2.2 Gy per fraction to 42 to 44 Gy in 20 fractions simultaneously to the nodes. It is near identical to the 1.8 Gy to 45 Gy so not real...

Radiation oncologists have a lot of freedom to use our alpha-beta model to create innovative fractionation schemes. We know that hypofractionation to the prostate is safe and effective at 2.5 Gy/fx to 70 Gy and 3 Gy/fx to 60 Gy. We also know that 1.8 Gy/fx to the pelvic nodal regions is a well estab...