Is it possible to give Inotuzumab ozogamicin in the front line setting for an older patient with Ph- Pre-B-ALL?   

Yes - there are encouraging data from early-phase trials looking at InO-containing regimens in the frontline setting. Some of these include: Alliance A041703 (InO followed by blinatumomab for older adults with CD22+, CD19+, Ph-negative B-ALL): Wieduwilt et al., Journal of Clinical Oncology 2023, su...