Is it reasonable to offer 3-days BEP regimen to a patient with high risk mixed germ cell tumor due to compliance issues?  

There is data from an old EORTC study comparing standard 5 day BEP to 3 day courses. However, 3 caveats:1. Only for good risk disease2. More ototoxicity and probably more nauseaThe regimen has cisplatin 50mg/m2 x 2 and etoposide 165mg/ m2 x 3 as outlined here from the abstract:"A cycle of BEP consis...

There are weeks of treatment where we have historically had to reduce due to holidays 5 days to 4 days of treatment as outpatient, but that would usually only apply to a single 5-day cycle during a 3 cycle regimen.

Little to add to @Lawrence H. Einhorn's answer. Not sure how it will help overall compliance though, particularly if there is more toxicity.