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Is it safe to give TKI therapy to a patient with metastatic renal cell carcinoma with brain metastasis?
Is there any specific precautions or concerns to consider with TKI initiation if the patient has vasogenic edema?
Answer from: Medical Oncologist at Academic Institution
Yes, it is safe, but I always treat the CNS metastasis first (e.g. SRS). The risk of bleeding in an untreated CNS metastasis with a VEGF TKI is otherwise unacceptable in my opinion. The edema should be treated with steroids as appropriate and I haven't experienced TKIs worsening CNS edema.
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