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Is there a minimum work-up necessary in patients with an ANA greater than 1:160 and no clinical symptoms suggestive of lupus (i.e., specific antibodies, UA)?
Answer from: at Academic Institution
My personal practice has been to get the "ANA subtypes" and a UA for prot/Cr ratio, but I do this with the idea of needing to have a complete picture. Clinical symptoms are still king.
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Answer from: at Academic Institution
In addition, I screen for other autoimmune diseases such as autoimmune liver disease and autoimmune thyroid disease. These of course have + ANA. ANA can occur in a variety of other illnesses which are characterized by hypergammaglobulinemia. Look for Sjogren's, sarcoid, lymphoma, hepatitis...