Is there a role for dose escalation beyond 50.4 Gy in neoadjuvant chemoradiation therapy for rectal cancer?  

There are probably a variety of opinions about this, but there is no proven role for doses higher than 50.4 Gy. Doses between 50Gy and 60Gy have been studied extensively, including a PhII trial reported by RTOG that was negative for pCR endpoint with 59Gy, and there is no dose response within this r...