Is there a role for intravenous temozolomide in place of oral for the 5-day dosing q 28 days after surgery/XRT+Temozolomide for glioblastoma multiforme?  

I have never used IV temozolomide, or seen it used by others in practice for GBM, and do not think it would offer a significant benefit over oral formulations as it has high oral bioavailability. I have seen and prescribed liquid oral temozolomide for patients with dysphagia.