Is there practical utility from obtaining CSF autoantibodies in patients with suspected neuropsychiatric systemic lupus erythematosus?   

I typically obtain serum and CSF autoimmune encephalopathy panels based on a patient's APE2 score. A score of 4 or more is predictive of having positive serum or CSF antibodies and can be applied to patients with neuropsychiatric lupus and help stratify who to test. I would start the workup with MRI...