Outside of teplizumab, what therapies do you recommend for preserving beta cell function in patients with early stage type 1 diabetes mellitus?  

Teplizumab is indicated to delay the progression of Stage 2 (hyperglycemia short of diabetes and 2 or more positive pancreatic islet cell antibodies) to Stage 3 diabetes--delayed the median time to onset of Stage 3 T1D by about 2 years longer than placebo in Stage 2 patients.  I am not aware o...

I agree with the nice summary of Dr. @Blevins. There is not strong data for the use of any of those agents. That said, I have seen a patient now in her mid-twenties (20s) who has been single antibody positive since childhood (sibling with Type 1 Diabetes Mellitus (T1DM)). Her glucose tolerance slowl...