N Engl J Med 2019 Dec 19
Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer.
Related Questions
Given recent approval of niraparib (Zejula) for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or prima...
New comment by at Baptist Medical Group ( January 3, 2021)
I agree. What is the PFS for BRCA and HRD negative patients?
Does your practice vary based on risk status (low vs high risk) or specific mutation status (BRCA+ vs HRD+) given PAOLA subset analyses?
New answer by at John Muir Medical Center (March 26, 2021)
I do not recommend routine use of bevacizumab in the upfront setting for any patient, regardless of mutation status. The results of GOG 218 should have been enough to put an e...
Are there clinical factors which help stratify? Does your practice vary based on mutation status (BRCA+ vs HRD+?)
New answer by at University of Oklahoma Health Sciences Center (March 8, 2021)
There is no rationale for starting bev if you aren’t going to continue it. GOG 218 clearly showed no benefit to stopping bev so outside of tox I don’t know w...
New answer by at University of Oklahoma Health Sciences Center (April 10, 2021)
There is a role for monotherapy niraparib with an HR that approximates a 30% reduction in the hazard of risk of progression or death. (PRIMA trial, NEJM 2019)
What specific platforms for determining somatic BRCA and HRD status do you use for a patient who does not carry a germline BRCA mutation?
New comment by Medical Oncologist at Arizona Hem/Onc ( March 20, 2021)
Excellent review for practicing oncologists. Great information, both basic and applied.
New answer by at UCSD Moores Cancer Center (August 31, 2021)
The information above is insufficient in informing a treatment recommendation. As defined, the implications of the BRCA2 VUS are unclear. In this setting, I would advocate tha...
New answer by Medical Oncologist at University of Utah School of Medicine (November 9, 2021)
ATM plays a central role in the repair of DNA double-strand breaks, which can be induced by ionizing radiation, chemotherapy drugs, or oxidative stress, or occur during normal...