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Should FISH studies be repeated when CLL patients under active surveillance have progressive disease warranting treatment?
What is the utility of repeating FISH studies to evaluate for clonal evolution if FISH studies were done at diagnosis?
Answer from: Medical Oncologist at Academic Institution
FISH studies should be performed on a newly diagnosed patient with CLL as well as those who have progressive disease and now warrant additional therapy. It is important to identify those patients who may have acquired additional cytogenetic abnormalities due to clonal evolution/resistance/etc as thi...
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