Should patients with mild subclinical hypothyroidism (TSH < 10 mIU/L) be treated with thyroid hormone replacement to improve their lipid profile?  

There is a well-known association between untreated primary hypothyroidism and hypercholesterolemia with subsequent improvement of lipid profile following thyroxine replacement. However, the link between hyperlipidemia and sub-clinical hypothyroidism is less well understood. The all-important questi...

Yes, I think it is very reasonable to consider thyroid replacement in patients with hyperlipidemia and subclinical hypothyroidism. While studies have shown that profound hypothyroidism decreases LDL receptor expression, it is quite likely that even mild hypothyroidism has some effect. T3 analogues (...