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Radiation Oncology • Neuro-Oncology
Should ultra-short course RT be standard for elderly or poor performance status patients with glioblastoma?
The recent Roa trial (JCO 9/21/15) found that 25Gy/5fx was non-inferior to 40Gy/5fx in terms of OS, PFS, and QOL. Is 25Gy in 5 daily fractions an appropriate treatment in older and/or poor PS patients?
Answer from: Radiation Oncologist at Academic Institution
The recent phase III randomized trial published by Roa et al. examining the efficacy of short course radiotherapy in elderly and/or frail patients with newly diagnosed GBM builds upon his previous work finding equivalent outcomes in elderly patients (age > 60 years) receiving 60 Gy in 30 fractio...
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Answer from: Radiation Oncologist at Community Practice
This study makes a strong argument for using short fractionation for patients with a poor performance status who are not candidates for chemotherapy and have short expected survival.The Nordic randomised trial also showed 34 in 10 fractions was better than 60 Gy in 30 fractions in the elderly.The ne...
Answer from: Radiation Oncologist at Community Practice
I find this useful for biopsy only IDH WT elderly patients; I have a hard time, though, knowing what size limitations there are? Does anybody have a 5cm cut off or anything like that? Also, how do you decide on treatment vs hospice and steroids?