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Gynecologic Cancers • Medical Oncology
Should women with adequately debulked ovarian cancer receive bevacizumab with chemotherapy in the adjuvant setting?
Answer from: Medical Oncologist at Academic Institution
The answer to this question is definitively NO.Two large, definitive studies (ICON-7 and GOG218 – including over 3400 patient combined) evaluated the impact of adjuvant chemotherapy with concurrent + maintenance bevacizumab. Analysis of mature data from ICON-7 demonstrated a significant ...
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Answer from: Medical Oncologist at Community Practice
For women with optimally cytoreduced disease In GOG 252: All treatment arms also received bevacizumab- the effect of the addition of bevacizumab is unknown. We await data on the subset of patients for whom a complete surgical resection was pathologically confirmed, as t...
Answer from: at Academic Institution
I have been offering Bevacizumab as maintenance, based on the GOG 218 data, with the caveat that it depends on BRCA testing. If the patient has either a germline or somatic BRCA mutation, then I would use olaparib as maintenance instead of bev.