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Radiation Oncology • Genitourinary Cancers
Under what circumstances would you recommend hypofractionated radiation for bladder cancer?
Assuming you are treating whole bladder only with concurrent chemotherapy, when would you recommend hypofractionated radiation (20 fractions) vs standard radiation? Would type of chemotherapy or patient age affect your decision?
Answer from: Radiation Oncologist at Academic Institution
In the BC2001 study (James N, NEJM 366:1477, 2012) that showed a benefit to chemoradiotherapy over radiotherapy alone, two fractionation schemes were allowed: 64 Gy in 32 fractions of 2 Gy or 55 Gy in 20 fractions of 2.75 Gy. Of the 360 patients in the trial, 40% had the shorter, 4 week fractionatio...
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