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Breast Cancer • Radiation Oncology
What adverse pathological features would be an indication for WBI (whole breast irradiation) after a patient receives IORT for early breast cancer?
An ASTRO APBI update readers are warned “the combination of IORT and WBI should be used only with caution and limited to women with higher risk features on final pathology.” Is there any specific recommendations in regards to what is high risk pathology aside from pathological features considered high risk on TARGIT-A (tumour-free margin smaller than 1 mm, extensive in-situ component, or unexpected invasive lobular carcinoma) ?
Answer from: Radiation Oncologist at Community Practice
Outside of the core TARGIT-A protocol, there are no other official protocol-defined pathological features warranting adjuvant EBRT. The protocol however allowed for centers to add other path risk factors justifying EBRT ie extensive LVSI +/- G3 +/- SMS .2-1cm +/- +SnLN.Mitigating risk of recurrence ...
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