What are your preferred non-benzodiazepine therapies for the hyperactive/agitated phase of methamphetamine withdrawal, both in the hospital and in the office?

Assume QTc is not prolonged, electrolytes are reasonably normal, and the patient is not already on heavy psychotropic polypharmacy.

Answer from: at Academic Institution

From an inpatient perspective: Dexmedetomidine [Precedex] IV if in the ICU or stepdown/transitional care unit that allows the infusion. It is well tolerated and, when effective, is a great tool to get the patient through an "acute" phase of his/her care. Ketamine IV [infusion] - there may ...

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What are your preferred non-benzodiazepine therapies for the hyperactive/agitated phase of methamphetamine withdrawal, both in the hospital and in the office?

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