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Pediatric Hematology/Oncology • Medical Oncology • Leukemia • NCI-CCC Tumor Board Question • ALL • AYA Tumor Board • USC
What dose of PEG-asparaginase do you recommend for teens with high BMI treated on a pediatric ALL regimen?
Would you plan straight pediatric dosing using 2500 Units/m2 or a cap of 3750 Units as used in some adult ALL regimens due to excess liver/pancreas toxicity?
Answer from: at Academic Institution
The peg-asparaginase dosing we use in ALL regimens for B and T cell is below:
Patients less than 21 years old – 2500 units/m2
Patients 21 years and older – 2000 units/m2
For obese patients (defined as > 95% BMI for patients less than 20 years old or BMI > 30 for pa...
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Answer from: Medical Oncologist at Community Practice
For older adolescents and young adult patients, the optimal dosing of peg-asparaginase is unclear. It is recognized that asparaginase toxicity increases with age, but also with certain comorbid conditions such as diabetes, liver disease, and obesity (BMI >30). The adolescent and young adult ...