What dose regimen would you use to treat a patient with locally advanced esophageal SCC of the mid-esophagus who refuses chemo and surgery, agreeing only to radiation alone?  

The 5Y survival of RTOG 8501’s RT alone arm was 0%. They used 64/32 Gy. So... I tend to think that RT alone is purely palliative and generally stick with 40/15 to provide palliation and hopefully some local control. 50/25 not unreasonable, but please don’t use the RT alone arm of the che...

I would stick with the standard 50.4Gy/28 fractions as established by the RTOG 8501 and Intergroup 0123 trials. Though there's an understandable impulse to give higher dose in this situation (and I myself have used an integrated boost to 56Gy/28 fractions in the past), there simply is no randomized ...