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Topics:
Hematologic Malignancies • Medical Oncology • Myeloma • Internal Medicine • Hematology • Multiple Myeloma
What induction regimen do you choose for high risk newly diagnosed multiple myeloma in light of the recent high risk focused studies?
Answer from: Medical Oncologist at Academic Institution
Two things are clear from the slew of high-risk enrichment studies and subgroup analyses that have been done.
In the age of upfront quadruplet therapy with an anti-CD38 monoclonal antibody, outcomes for patients with one high-risk cytogenetic abnormality are very good, even in the absence of prolon...
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Answer from: Medical Oncologist at Community Practice
It's probably not the induction that's interesting since the majority of high risk patients respond to most 3-4 drug cocktails.
What about Dara-KRd followed by transplant then Dara-KP maintenance?
Since no consolidation or CART in the second line, this might be the most active combination fo...
Answer from: Medical Oncologist at Academic Institution
I agree with @Craig C. Hofmeister on all fronts! I have no doubt that @Saurabh Zanwar is referring to the flurry of new studies that were either presented at IMS last week and/or published. For example:
The final MASTER trial results of Dara-KRd plus transplant led by Dr. Costa and colleagues (not ...
Answer from: at Community Practice
Would go with Dara KRD followed by double auto SCT and dara and len maintenace as in IFM 2018-04 study. Not sure if Isa KRD + double transplant as in GMMG concept is any better.