What is the best fractionation for head and neck patients who cannot receive systemic therapy due to KPS or medical comorbidities?

In my experience, using the DAHANCA regimen (once daily 4 days a week, twice daily once a week), but treating only PTV1 in the second daily fraction, is quite well tolerated. The original DAHANCA treated all targets twice daily. However, using IMRT it is possible to avoid prophylactically irradiated...

If a patient has a cancer appropriate for definitive chemoradiation and has indications for chemotherapy but is not considered medically able to have chemotherapy, then I recommend accelerated fractionation. If the KPS is not even high enough for accelerated fractionation, then the goal should proba...

See MARCH update in the Lancet Oncology