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What is the optimal dose fractionation for treating liver metastases in the central liver causing obstruction of biliary flow?
Will higher doses per fraction increase the risk of fibrosis and cause permanent impediment to biliary flow?
Answer from: Radiation Oncologist at Academic Institution
This question is somewhat controversial, which is surprising to me. The standard ablative dose for ablation of liver mets is 100Gy BED10. This results in local tumor control of 90% at 2 years for CRC liver mets, but drops off to 70% at 5 years. Other histologies may be more sensitive. The biliary tr...
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