What is the timing of onset of alectinib induced ILD, and is there any correlation between dose and the occurrence of ILD?   

There is wide variability in the timing of onset of ALK TKI-induced ILD. In a single-institution retrospective analysis published by Koshikawa et al., PMID 32237210, onset specifically of alectinib-induced ILD ranged from day 9 to 531. Risk of ALK TKI-induced ILD was associated with older age and wo...