What is your approach to women with early-stage hormone responsive breast cancer intolerant of AI's who want to remain on endocrine therapy but have contraindications to tamoxifen?  

Assuming you have tried all 3 AIs along with maximal supportive care for the side effects leading to intolerance and you truly have an absolute contraindication to tamoxifen then you don't have any real proven other options in a postmenopausal patient. Sometimes the patient will quit therapy altoget...