What is your preferred approach to young adults with CNS pure germinoma (markers negative, single nodule, CSF negative)?
Some prefer radiation alone, while others do chemotherapy followed by RT (possibly to lower dose vs. RT alone).
Answer from: Radiation Oncologist at Academic Institution
This is a great question as we tried to evaluate the benefits and trade-offs between both approaches with ACNS0232 but the study closed prematurely because of poor accrual. As with many other studies that have drastic differences in the strata which are randomized, it can be tough to ask patients an...