What is your treatment approach for patients with MDA5-positive amyopathic dermatomyositis, who also have anti-CCP positive rheumatoid arthritis but no clinical lung involvement?  

What clinical symptom or sign being treated is the key? If MDA-5 autoantibodies are associated with rash but no ILD or myositis, treatment should generally be directed at the skin. This is an active area of study. The presence of anti-CCP+ RA without ILD might prompt the use of rituximab given its p...