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Topics:
Neurology • Movement disorders
What leads you to consider a non-oral form of levodopa for the treatment of Parkinson’s disease?
In light of new findings on the efficacy of continuous subcutaneous levodopa-carbidopa infusion (Espay et al., PMID 38499015).
Answer from: at Academic Institution
I agree with Dr. @Amlang's excellent review.
Consider non-oral forms of medication when there are concerns about dysphagia. Additionally, if the dosing frequency becomes too high (e.g., five times a day of levodopa), and the patient finds it difficult to maintain this schedule, consider long-acting...
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Answer from: at Academic Institution
At the moment, most levodopa formulations are oral medications. There are two non-oral forms of levodopa that are currently in clinical use; an inhalation powder and a continuous enteral solution.
The levodopa inhalation powder is a rescue, on-demand medication used as needed for OFF periods. Given...