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What medications would you have a patient avoid with an IgE mediated reaction to cyclobenzaprine?
The structure is similar to tricyclic antidepressants, so I was planning to avoid those medications but unsure if there are other medications also.
Answer from: at Academic Institution
The mechanism of immediate hypersensitivity to cyclobenzaprine is likely MRGPRX2-mediated rather than IgE-mediated. MRGPRX2 is a G-protein coupled receptor (GPCR) predominantly expressed in human mast cells. Upon activation, MRGPRX2 triggers mast cell degranulation and anaphylactic reactions. MRGPRX...
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