For which patients could you consider direct oral amoxicillin challenge as opposed to skin testing for penicillin allergy de-labeling?   

If a patient can be identified as low-risk by history they should be considered for either historical removal of the label of direct oral challenge. If the history is not compatible with allergy (e.g. they have a family history or have tolerated another drug like Augmentin), historical de-labeling i...