What non-taxane chemotherapy can you partner with trastuzumab/pertuzumab for HER2+ breast CA if neuropathy either at baseline or with treatment becomes prohibitive?  

For less neuropathic agents there are safety/efficacy data from the PHEREXA trial combining capecitabine with pertuzumab and trastuzumab (Urruticoechea et al JCO 2018). We also presented data on using gemcitabine with pertuzumab and trastuzumab in a small phase 1/2. (Soliman et al JCO 2016).  T...

I just read this in practice update and though relevant so sharing to help answer your question  In the randomized, phase III, MARIANNE trial, the authors evaluated the efficacy of trastuzumab emtansine (T-DM1), T-DM1 plus pertuzumab, and trastuzumab plus a taxane in 1095 patients with HER2-po...