What radiation dose would you use to treat a symptomatic osseous lesion secondary to AL-amyloidosis?   

Extrapolating from our tracheobronchial experience, we’ve used 20 Gy in 10 fractions to target the underlying plasma cells that produce amyloid production. We’ve also used this regimen for ocular and GU (ureteric and bladder) amyloidosis. If there are obstructive or symptomatic lesions, ...

20 Gy in 10 fractions. I refer you to this PRO article that I co-authored with colleagues at UNC. Hall et al., PMID 36088238