What ratio of lumpectomy cavity volume to normal breast tissue do you consider reasonable for treating a patient with APBI?

For example, if partial breast RT results in the prescription dose to 80% of the breast, is that reasonable? 50% of the breast?

Answer from: Radiation Oncologist at Community Practice

In the Italian study, they used 50% prescription dose to 50% or less of breast volume outside PTV. I generally limit PTV volume to the total breast volume ratio of <25-30% to decide if PBI is an appropriate treatment, as dose constraints to the uninvolved breast get harder as PTV volume percentag...

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Radiation Oncologist at Mass General Physicians Organization
I am somehow more conservative with the PTV/breast...

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What ratio of lumpectomy cavity volume to normal breast tissue do you consider reasonable for treating a patient with APBI?

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