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What treatments have you found most effective for cholestatic pruritus?
I have a patient with recently diagnosed primary biliary cholangitis/cirrhosis (PBC) with SSc. Her laboratory values are within normal limits, but endorses pruritus that breaks through despite cholestyramine and ursodiol. Any other recommendations? Potential JAK/STAT inhibitors?
Answer from: at Community Practice
My experience is mainly in Sjogren's or Sjogren's with PBC, ursodiol has been effective. Occasionally, I have used hydroxyzine or H1+H2 blockers. In Sjogren's where the skin biopsy has shown significant lymphocytic infiltration, mycophenolate or a calcineurin inhibitor trial has lead to the resoluti...
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