What would be your adjuvant treatment approach for patients with hormone receptor-positive breast cancer who have not responded to neoadjuvant aromatase inhibitor endocrine therapy?

There are some details that are important in answering this question as for example, how lack of response was defined and how long was the patient on neo-adjuvant endocrine therapy. Response to endocrine therapy takes several weeks to a couple of months and neo-adjuvant trials showed a very low rate...