What would be your approach to first line therapy for patient with metastatic HER2 positive breast cancer with CHF (LVEF <50%)?

Is there absolute LVEF threshold you would not use HER2 targeted therapies?

Answer from: Medical Oncologist at Community Practice

I would have cardiology on board and see if EF can be improved with medication. If close to 50% and cardiology feels it's stable/can be improved and can be closely monitored, I may go ahead after coordination with them.

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What would be your approach to first line therapy for patient with metastatic HER2 positive breast cancer with CHF (LVEF <50%)?

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