When administering breast brachytherapy (10 fxs BID), is it critical that treatment start on a Monday (not straddle one weekend)?  

NSABP B-39 allowed PBI to be given over 5-10 days, so we stay within this time frame and haven't seen any problems.

Ideally, the applicator will stay in for only 1 weekend rather than 2 by starting on a Monday. However, not all cases can proceed in this way and there may be circumstances that necessitate leaving the applicator in over 2 weekends. Alternatively, schedules may be modified (ex. 32 gy/ 8 fractions) t...