When do you consider complement inhibitors or FcRN inhibitors in patients with myasthenia gravis?  

In my opinion, those meds should be considered for a patient with AchR antibody-positive MG who has suboptimal control of MG symptoms on: Pyridostigmine + prednisone + oral immunosuppressant drugs like azathioprine or MMF. Pyridostigmine + oral immunosuppressant + severe intolerance to steroids ...

In theory, I agree with Dr. @Manousakis but for me, the answer is more complicated. MMF and aza usually take many months to kick in, and it is not particularly useful to get the disease under control quickly. The concept that they should be used as "steroid-sparing agents" is good but one does add ...