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Topics:
Gastrointestinal Cancers • Medical Oncology • Colorectal Cancer • Liver and Pancreas Tumors • Gastroenterology
When do you perform HER2 testing in patients with colorectal cancer?
Answer from: Medical Oncologist at Academic Institution
HER2 amplification is seen in a small but distinct subset of colorectal cancer. This subset has 2 unique characteristics:
They are predominantly RAS wild type tumors.
They do not respond to anti-EGFR agents, i.e. HER2 amplification is a negative predictor of anti-EGFR antibody (cetuximab and pan...
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