Which systemic therapy (if any) do you offer premenopausal women with a second TNBC local resectable recurrence and an extensive chemotherapy history?  

Patients with locoregional recurrence definitely benefit from repeated chemotherapy for sure (as shown in CALOR trial and our own experience). The question here is after exhausting anthracycline and taxane-based therapy as most patients would have been already, what might be the best regimen?  ...