Will you use vadadustat in place of an ESA in treating anemia of chronic kidney disease?  

Vadadustat is approved by the FDA only for patients who have been on dialysis for at least 3 months. It is not approved for patients with CKD not on dialysis. Its efficacy and safety are comparable to that of ESAs. I would consider using vadadustat in two patient populations: those on home dialysis ...

I would use traditional ESA due to their known safety profile and reserve agent for an unresponsive patient. With more data, will likely change.