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Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • Her2+ • Moffitt Cancer Center • NCI-CCC Breast Tumor Board Question
Would weak PR positivity make you consider adjuvant endocrine therapy for a young pre-menopausal woman with a HER2 positive, ER negative breast cancer?
If yes, would you offer tamoxifen or ovarian suppression plus AI?
Answer from: Medical Oncologist at Academic Institution
I would discuss the uncertainties, and would offer tamoxifen at the most (I would not subject the patient to the toxicities of OFS and AI). I would also have a low threshold to discontinue tamoxifen if there are toxicities. If there are minimal to no side effects, it may be worthwhile getting the th...
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