Would you consider a treatment break for a patient with metastatic urothelial carcinoma who achieved a near-complete response to enfortumab?
Previously progressed on platinum and Pembrolizumab
Answer from: Medical Oncologist at Academic Institution
The answer to this question is highly dependent on the specific clinical context. However, for a patient who has a deep and durable response to enfortumab vedotin monotherapy and has been on treatment for a prolonged period of time (again context-dependent, but at least a few months), I think it is ...
Answer from: Medical Oncologist at Academic Institution
Reasonable points by Dr. @Koshkin. The major challenge is the lack of prospective data (we need trials to assess de-escalation questions with EV alone or EV/pembro). Until then, my approach depends on the clinical context (as Dr. Koshkin) wrote, esp. toxicity, with dose adjustments as needed. The da...
Comments
Medical Oncologist at Intermountain Health Care Agree. Balance potential efficacy loss vs quality ...