Would you consider adding atezolizumab to a different chemotherapy/platinum-doublet backbone from the IMpower 133 trial for a new ES-SCLC patient?
Would you consider adding atezolizumab to a cisplatin/irinotecan regimen, or cisplatin instead of carboplatin?
Answer from: Medical Oncologist at Academic Institution
No I would not, primarily for these reasons:
1) There are no clinical data of which I am aware regarding the addition of atezolizumab to irinotecan and cisplatin for any tumor type.
2) Irinotecan/cisplatin is more toxic than etoposide/platinum regimens, with no improvement in efficacy in 1L extens...
Comments
Medical Oncologist at Florida Hospital Cancer Institute I agree with @James Stevenson. Without safety data...
Medical Oncologist at Orange Reg Medcl Ctr I agree.
Medical Oncologist at University of Virginia I agree as well.
I agree with @James Stevenson. Without safety data...
I agree.
I agree as well.