Would you consider adjuvant capecitabine as well as trastuzumab in a patient with ER/PR negative, HER2 positive breast cancer treated with neoadjuvant chemotherapy /trastuzumab/pertuzumab who has residual disease on path?

The CREATE-X trial did not include HER-2 positive patients but the ER-negative population benefited from capecitabine. Would you consider capecitabine + a HER-2 agent in this setting? With the new data from the KATHERINE trial, would you substitute ado-trastuzumab?

Answer from: Medical Oncologist at Academic Institution

Treatment with adjuvant TDM1 would be the recommended approach based on the KATHERINE data.

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Would you consider adjuvant capecitabine as well as trastuzumab in a patient with ER/PR negative, HER2 positive breast cancer treated with neoadjuvant chemotherapy /trastuzumab/pertuzumab who has residual disease on path?

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