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Radiation Oncology • Genitourinary Cancers
Would you consider applying the principles of STAMPEDE with <5 oligometastatic non-regional lymph nodes from prostate cancer?
STAMPEDE arm H uses the CHAARTED definition for bone metastases in the axial skeleton. There is no mention of patients with non-regional nodes. Would you offer 55GY/20fx to men with non-regional (common iliac) nodes?
Answer from: Radiation Oncologist at Community Practice
There isn't "no mention" of non-regional nodal disease in STAMPEDE, nor does one have to extrapolate the principles.From the paper directly: "Low metastatic burden disease is sometimes known as oligometastatic. Although this term is widely used, it is imprecise and potentially misleading because it ...
Comments
Radiation Oncologist at UPMC Hillman Cancer Center
Agree - as @Sushil mentioned above, for these men,...
Agree - as @Sushil mentioned above, for these men,...
Answer from: Radiation Oncologist at Community Practice
There was a subset analysis of STAMPEDE (Ali et al., PMID 33599706). They looked at refined definitions of metastases which looked at: bone Mets, visceral Mets, and non-regional nodal disease. Prostate RT had no survival benefit with visceral Mets. It appeared best with 3 or less bone Mets...
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