What dose-fractionation do you use for salvage HDR brachytherapy for biopsy proven locally recurrent prostate cancer after prior external beam radiotherapy?

How do clinicopathologic factors affect your selection of dose-fractionation?

Answer from: Radiation Oncologist at Academic Institution

I believe most people use 27 Gy in 2 fractions (two insertions spaced by 1-2 weeks) based on a prospective, pilot study from Sunnybrook (NCT01583920; Corkum et al., PMID 35718075). Another dose schedule used by some is 32 Gy in 4 fractions (single insertion, > 4 hrs between fractions over 30 hour...

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Radiation Oncologist at Community Health Network
I have used Dr. Syed's fractionations of 600 Cgy x...

Answer from: Radiation Oncologist at Academic Institution

I used 27 Gy in 2 fractions over 2 implants for "focal" salvage. I used to use 36 Gy in 6 fractions over 2 implants for treating the whole gland (Lee et al., PMID 17197119, Chen et al., PMID 23474112, Wu et al., PMID 34077809).

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Radiation Oncologist at Rush Medical College of Rush University
Similarly, I used 27 Gy in 2 fractions over 2 impl...

Radiation Oncologist at Vice Chair, Northside Hospital Cancer Institute
I also use 13.5 Gy x 2 fractions over 2 implants f...

Radiation Oncologist at Moffitt Cancer Center
I use 13.5Gy x 2, whole gland, hydrogel spacer whe...

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What dose-fractionation do you use for salvage HDR brachytherapy for biopsy proven locally recurrent prostate cancer after prior external beam radiotherapy?

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