What dose-fractionation do you use for salvage HDR brachytherapy for biopsy proven locally recurrent prostate cancer after prior external beam radiotherapy?
How do clinicopathologic factors affect your selection of dose-fractionation?
Answer from: Radiation Oncologist at Academic Institution
I believe most people use 27 Gy in 2 fractions (two insertions spaced by 1-2 weeks) based on a prospective, pilot study from Sunnybrook (NCT01583920; Corkum et al., PMID 35718075). Another dose schedule used by some is 32 Gy in 4 fractions (single insertion, > 4 hrs between fractions over 30 hour...