Would you consider chemoimmunotherapy in a patient with hormone positive breast cancer treated with chemotherapy who has progressed to triple negative breast cancer?  

If the patient had treated ER+ early stage disease and the metastatic recurrence was retested to be TNBC and CPS>=10, I would treat using the KY355 regimens in the 1st line setting.  If you are asking about ER+ metastatic disease that was treated as such then rebiopsied later on at prog...